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finally, in terms of limitations, it highlights the heterogeneity in evidence [e.g., variations in Omega-3 dosing across RCTs (65)] and population-specific biases [e.g., vitamin D studies focusing on IBD patients (169)]

The bioavailability of food folate is estimated to be around 50%, i.e., half that of folic acid taken with water on an empty stomach, due to losses during digestion and absorption