glutathione cho cell culture Intracellular metabolite profiling and in vivo monitoring of redox state unravel the effect of temperature downshift on cell growth, antibody titer and product quality CHO cell clone K1 Cells Perfusion reduces bispecific antibody aggregation
Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction induced glutathione oxidation and ER stress in CHO cells Scientific Reports Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fedbatch process Kirsch 2022 Biotechnology and Bioengineering Wiley Online Library Glutathione and mitochondria Frontiers Exploring CHO cell stability during prolonged passaging via eXplainable AI driven flux balance analysis npj Systems Biology and Applications
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