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ACS Applied Nano Materials

Under basal conditions, Nrf2 is sequestered in the cytoplasm by Kelch-like ECH-associated protein 1 (Keap1), which targets it for ubiquitin-mediated degradation

This helps in decreasing skin break-out, post-fiery hyperpigmentation, and melasma

Data have suggested this occurred through modulation of transforming growth factor beta (TGF-) pathway proteins, specifically mothers against decapentaplegic homolog 3 (Smad3)