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For example, the classic tumor suppressor p53 has been shown to induce ferroptosis under certain conditions [32, 33], and numerous studies have revealed molecular interactions between ferroptotic and apoptotic pathways [34,35,36]

The treatment strategies for the repair of intervertebral disc degeneration

To critically appraise mechanisms and levels of evidence ( in vitro, in vivo , clinical) for vitamin E and C, glutathione and its precursors, polyphenols (quercetin, resveratrol, curcumin), Crocus sativus carotenoids (crocin/safranal), and indirect modulators (e.g., omega-3, folinic acid), emphasizing study quality, translational relevance, and limitations