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In response to rising levels of youth e-cigarette use, on September 11, 2019, the federal administration announced a future ban on the sale of flavored e-cigarettes, but final guidance from the FDA, issued January 2, 2020, only prohibits the sale of flavored cartridge-based (closed system) e-cigarette products other than menthol or tobacco flavor

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[4] Article 2.2 of the Agreement on Technical Barriers to Trade (TBT Agreement)

Among other things, chemicals in cigarette smoke cause the cells that line blood vessels to become swollen and inflamed, which leads to narrowing of those vessels