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The peptide was first identified in 1973 by Loren Pickart during research on human plasma, where he observed that a small copper-peptide complex was present in younger blood samples at higher concentrations than in older ones

Subsequently, during proliferative and remodeling phases, TIMP expression increases in coordination with new matrix deposition, preventing premature degradation of nascent collagen and elastic fiber networks

Tkalcevic, V., et al

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