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Other protocols allow short-term human organoid growth 40 or apply a more complex collagen sandwich technique in combination with the use of small molecules (CHIR and valproic acid) to maintain growth 41

The protein ions detected in the mass range m/z 1400014250 reported in Fig

In parallel, the exploration of non-canonical targets, such as immune-modulatory molecules or metabolic antigens, aims to circumvent classical resistance pathways and reduce selective pressure on conventional tumor markers [253, 254]