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Hauck WW, DeStefano AJ, Cecil TL, Abernethy DR, Koch WF, Williams RL

On one hand, it activates the Nrf2 pathway via VDR, inducing the expression of antioxidant enzymes such as superoxide dismutase (SOD), GPX, and CAT to increase ROS scavenging, while simultaneously downregulating iNOS and NADPH oxidase to limit ROS production ( 2+ CAMKK2AMPK signaling pathway ( Clinical and preclinical studies support these antioxidant effects

Interactions between SCFAs and their receptor HCA2 are noteworthy, especially given that HCA2 expression is downregulated in lesions of psoriatic skin

At the end of the infusions, tumor, adjacent muscle, and blood plasma were collected and subjected to LC/MS (Fig