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The findings are preliminary and need to be confirmed in a larger patient cohort over an extended treatment period to enable longer-term impacts of DMF on disease outcomes and metabolic changes to be more fully explored

In the dynamic simulation of CME_a, the conformations where these two residues form hydrogen bonds with the ligand represent more than half of all conformations with hydrogen bonds

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Reynolds, J., Lai, R., Woodhead, J., Joly, J., Mitchell, C., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N., Benayoun, B., Merry, T., & Lee, C