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In addition, increasing GCH1 or increasing BH4 caused increased T-cell activation and proliferation (not good, in some autoimmune diseases).[ref] In people with multiple sclerosis (MS), researchers have found that they have low BH4 levels and high neopterin levels, suggesting excessive consumption of BH4 presumably in activated immune cells

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J Am Chem Soc 93(9):23252327 Kingston D, Newman DJ (2007) Taxoids: cancer-fighting compounds from nature

PMID: 21939731 | DOI: 10.1016/j.mce.2011.09.005 [23] Meeker JD, Ferguson KK