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References 1 SiegelRLMillerK DWagleN SJemalA

Annu Rev Med 54 : 453471 DelParigi A et al

Specifically, system xc is inhibited by high extracellular Glu concentration, and decreasing intracellular GSH leads to peroxidase 4 (GPX4) inhibition and lipoxygenase (LOX) activation