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Because of the pentose phosphate pathway bottleneck and the lack of G6PDH enzyme, the body cannot quickly synthesize the D-Ribose needed to salvage and rebuild the lost ATP

(2007) The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

2i), and the population of ROS low cells was significantly enriched in H1299 cells treated with cisplatin alone but was rapidly eliminated when combined with shCPT1A or etomoxir (Supplementary Fig