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Chris Sweeney wrote in Boston Magazine that there is little evidence from veterinary associations or veterinary medical schools to support whisker fatigue as a thing. Furthermore, the World Small Animal Veterinary Association (WSAVA) told Preventive Vet in 2017 that it has no information specific to this condition, whether through our scientific working groups or as part of our continuing education offerings. But heres the rub on whisker fatigue: The lack of current evidence doesnt necessarily mean that it doesnt or couldnt exist

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[PubMed Citation] Following intravenous administration of hydroxocobalamin significant binding to plasma proteins and low molecular weight physiological compounds occurs, forming various cobalamin-(III) complexes by replacing the hydroxo ligand