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H 2 O 2 -dependent signaling changes to these regulatory enzymes are known to impair cellular glucose uptake, thus contributing to onset and progression of diabetes as well as neurological disorders [65, 66]

endocytosis and/or transcytosis of GSH transporter-targeted ligands may be assayed by in vivo bioimaging techniques using for instance near-infrared dyes or radioactive labels conjugated thereto, resulting in at least 10, 20, or 50% enhanced retention in CNS area of the ligand at given time-points (based on region of interest (ROI) pixel quantification), as compared to appropriate control conditions (e.g., comparison to reference compounds lacking GSH moieties)