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Phase II study of personalized peptide vaccination for castration-resistant prostate cancer patients who failed in docetaxel-based chemotherapy

A randomized double-blind placebo-controlled phase IIB trial treated patients with oral leukoplakia using curcumin (3.6 g daily for 6 months) and noted a significant and durable clinical response, including reduction in lesion size and histopathological improvement in terms of reduced dysplasia in some cases (Kuriakose et al., 2016)

GGT activity was reported to be particularly high in tissues with secretory and absorptive function such as kidney, biliary system, intestine and epididymis and the enzyme activity is greatest in the ductal luminal surface of these tissues (3)