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Whether NAC is effective in replenishing GSH regardless of GSH deficiency is somewhat controversial

In pancreatic cancer, LAT2 ( SLC7A8 ) was shown to decrease gemcitabine sensitivity by regulating glutamine-dependent mTOR activation to promote proliferation and inhibit apoptosis (Feng et al., 2018)

These results show the perspective on the early prevention and treatment of HD with metformin

As the core component of class III phosphatidylinositol 3-kinase complex I (PtdIns3K) [99], BECN1 triggers different cell death by cooperating with different partners, and it is also a factor for occurrence of ferroptosis [100]