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Description

Frederick Crane and colleagues (1) at the Enzyme Institute of the University of Wisconsin in Madison first isolated it in 1957 from beef heart mitochondria as a yellow-orange lipophilic substance with redox properties, and it was proposed to function as a coenzyme for mitochondrial electron transfer

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Radiotherapy-activated NBTXR3 nanoparticles promote ferroptosis through induction of lysosomal membrane permeabilization

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That's why supplementing with the active form methylfolate can be important: you're skipping the bottleneck

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