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The above signalling pathways triggers inflammatory cascade leading to the production of numerous inflammatory cytokines, pro-fibrotic molecules, Interleukin (IL)-1, IL-6, tumour necrosis factor (TNF-) Monocyte Chemoattractant Protein-1 (MCP-1), Connective Tissue Growth Factor (CTGF), Platelet-Derived Growth Factor (PDGF) and Vascular Endothelial Growth Factor (VEGF) in the membrane (Balzer, 2020

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Antidepressant activity of fluoxetine in the zinc deficiency model in rats involves the NMDA receptor complex