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Furthermore, mild microwave ablation at 48 degrees celsius has been shown to increase apoptotic rate in an in vitro and in vivo osteosarcoma model, when added to transforming growth factor (TGF) beta-1 inhibitor and heat shock protein 90 (HSP90) inhibitor, suggesting the immunomodulatory effects of microwave ablation may become increasingly appreciable in the era of immunomodulatory medications (71)

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