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In addition, concomitant treatment with other neurotoxic chemotherapeutic agents, or pre-existing neuropathies, may additionally increase the risk of developing CIPN (Chaudhry et al., 2003)

6 Synergistic mechanisms and combination therapies 6.1 Chemo-curcumin nano-delivery systems Synergistic therapy utilizing nanoparticle co-delivery systems represents a pivotal advancement in enhancing curcumins anticancer efficacy by leveraging complementary mechanisms with conventional chemotherapeutics