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In one sentence, the mechanism is receptor-mediated: GHRP binding to GHS-R1a activates a Gq/11-coupled phospholipase C cascade that mobilises intracellular calcium and triggers exocytosis of stored GH from the anterior pituitary, independent of hypothalamic GHRH signalling

Since the launch of MELSMON in 1956 and LAENNEC in 1974 to the present, there has not been a single case of infection reported, including Creutzfeldt-Jakob disease

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