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In addition to -synuclein, there is mounting evidence implicating other genetic mutations such as in Parkin, leucine-rich repeat kinase 2 (LRRK2) and DJ-1, alongside environmental factors (including exogenous neurotoxins, age and diet) as potential contributors to the etiology of PD (99,100)

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Additionally, a prior study has indicated that inhibiting endogenously synthesized cholesterol intensifies ApoE4-induced neuronal death (Michikawa and Yanagisawa, 1998)