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Specifically, our achieved limits align perfectly with other advanced non-derivatized HILIC-MS/MS methods targeting broad metabolic profiles, which typically report LODs in the range of 0.125 ng/mL [41, 42]

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The data observed in each group were tested for normality using the Kolmogorov-Smirnov test and all parameters were not statistically significant which indicate that data are parametric (normally distributed), so the results were expressed as mean SD

Miyata Y, Mukae Y, Harada J, Matsuda T, Mitsunari K, Matsuo T, Ohba K, Sakai H