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These mast cell mediators provoke potent inflammatory responses that can include urticaria (AKA hives-skin rash and swelling), angioedema (swelling beneath the skin surface), bronchoconstriction (airway constriction), diarrhea, vomiting, hypotension (low blood pressure), cardiovascular collapse, and death, all within a matter of minutes

Verdict: Best for overall skin glow and internal skin health, not instant dramatic change

5,6 Nonetheless, an alteration of immune responses has been described: NKs increase, low IgG titers, IL-2 and INF reduction

This research has been funded by Deputy for Research and Innovation, Ministry of Education through Initiative of Institutional Funding at University of Hail Saudi Arabia through project number IFP-22017