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Thereby, the expression of several adhesion molecules and cytokine secretion was altered in bone marrow stroma cells under overload conditions impairing their capacity to support hematopoietic cells growth (105, 107)

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In oral squamous cell carcinoma, RECK is often downregulated due to promoter hypermethylation or genetic changes, leading to an increased MMP activity, which enhances tumor invasion and metastasis (32)

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