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Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43

All means were obtained using LSMEANS

These samples were then imaged using a Zeiss LSM 880 confocal microscope, allowing high-resolution analysis of cellular morphology [2]

Seek urgent medical attention if you experience: Severe allergic reactions (difficulty breathing, facial swelling, severe rash) Unexplained muscle pain, weakness, or dark urine Significant changes in heart rhythm or chest pain Severe gastrointestinal symptoms or signs of liver dysfunction (jaundice, dark urine, pale stools) Regular monitoring may be appropriate for individuals with chronic conditions or those taking higher doses long-term