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Description

At present, the mechanisms of Hcy-induced endothelial injury include induction of inflammation and cell death, disturbance of NO production, ROS accumulation and oxidative stress, dysfunction of H 2 S signaling pathway, cellular hypomethylation, protein homocysteinylation, and lipid metabolism disorder

Homocysteine levels were also correlated with obesity, smoking, defects in the MTHFR gene, and deficiencies of vitamin B12 and folate.23 Evidence from clinical trials for the beneficial role of a regimen of supplemental folate, vitamin B6, and vitamin B12 on CVD risk is lacking

Gladden, 2006