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22 Insulin signaling pathways Physiologically, insulin binds to the extracellular subunit of insulin receptor, a receptor tyrosine kinase which recruits and phosphorates insulin receptor substrate (IRS)-1, thus activating phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling and diverse downstream pathways to maintain the glucose homeostasis

Procyanidin B2 protects TR-iBRB2 cells against hyperglyc emia stress by attenuating oxidative stress and inflammasome activation via regulation of redoxosomes/NF-kB signaling

Glutathione peroxidase protects cells from oxidative damage by reducing peroxides

The assembly of salamander genomes is challenging because of its large size and excessive number of repetitive regions (axolotl genome