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Cultivation of flue-cured virginia tobacco began during the Meiji period (1868-1912)

The trial was not randomized and controlled, and thus causality cannot be determined, partly because of an unexpectedly high cessation rate which resulted in a control group without sufficient power

Researchers measured the impact of four common pollutants: fine particulate matter (PM2.5 and PM10), nitrogen dioxide, sulfur dioxide, and carbon monoxide

Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014 [accessed 2015 May 21]