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There are two important epigenetic mechanisms methylation plays a central role in both: DNA methylation The switching on and off of particular genes through methylation

it also promotes Tregs development and decreases NK cell cytotoxicity, granule exocytosis, and IFN- secretion through the pathway by protein kinase C (PKC), phosphoinositide 3-kinase (PI3K) , extracellular-signal-regulated kinase (ERK), and protein kinase B (AKT) activation [108, 109]

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