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The first group of patients for whom metformin may be inappropriate is individuals with specific kidney conditions ( 8 Conclusion The investigation of metformin as an antioxidant intervention has yielded promising outcomes in various studies both in vitro and in vivo

Cells 9:383

Liver-metastatic breast cancer cells display a distinct metabolic reprogramming characterized by accumulation of glucose-derived lactate and reduction in the TCA cycle and OXPHOS (138)

Valerate serves as a metabolic regulator that reprograms lymphocytes via mTOR signaling in CD4 + T cells and B cells, facilitating glucose oxidation, increasing acetyl-CoA levels and stimulating the release of immunosuppressive factor IL-10 [44]