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Numerous enzymes (the various members of the ATG family) participate in the autophagic pathway, but an early step in this process is the cleavage of the microtubule-associated proteins 1A/1B light chain 3A (LC3 or ATG8) by the cysteine protease ATG4B 2

Among the most promising targets for such strategies are certain types of cancer, neurodegenerative diseases (e.g., Alzheimers disease and Parkinsons disease), and chronic inflammatory disorders ( Additionally, studies evaluating the role of ATs in human diseases rarely define which specific ROS are involved, their sources, how they reach their molecular targets, and which targets are affected, and why

Libiad, M., Vitvitsky, V., Bostelaar, T., Bak, D

Y-YY contributions to design of the work and revised the work