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10.1016/j.redox.2015.06.020 188 VermaA

It is an alteration in the balance of prooxidant /antioxidant system in favour of prooxidant with attendant lethal effects with resultant damage to the cellular macromolecules (Fig

It is less irritating than salicylic acid due to its large molecule size

Drug Metab Dispos 23(3):406414 Shear NH, Spielberg SP, Grant DM, Tang BK, Kalow W (1986) Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity