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J Med Internet Res 15(4):e59 Gordan R, Gwathmey JK, Xie LH (2015) Autonomic and endocrine control of cardiovascular function

Today, many of the most celebrated cigars in the world are handmade in the Dominican Republic, including Arturo Fuente, Ashton, Macanudo, and Davidoff, in addition to several Cuban-heritage labels like Cohiba, Montecristo, Romeo y Julieta, and H

While the precise mechanisms by which smoking increases cardiovascular disease are still being discovered, it has been shown to exert direct myocardial effects, such as increasing myocardial oxygen demand, lowering the threshold for angina, and Impairing exercise performance (Figure 2)

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