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[238] fabricated poly(l-histidine) coatings on ceria nanocages using an EDC chemistry procedure, and they revealed that these coatings could enhance corneal penetration while allowing pH-responsive release of bioactive cargos, including acetylcholine chloride and SB431542, for the treatment of chemical eye injury

Skin appendages were also involved, evidenced by hair follicle and eccrine coil necrosis

The subsequent disruption of the IEB allows the passage of antigens into the mucosa leading to further inflammation