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Raised, rolled, reddened, or darkened wound edges might reflect delayed healing or pathological changes, while dryness, flaking, redness, tension, shininess, or pigmentation changes in adjacent skin can signal abnormal tissue responses [27]

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Tier 3 also includes medications that have some evidence in the elderly but that have not been adopted for use in most practices

Haugaard SB, Andersen O, Hansen BR, Orskov H, Andersen UB, Madsbad S, Iversen J, Flyvbjerg A: Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients