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Several studies identified variations of methylation levels in different areas of the mitochondrial genome, supporting the hypothesis that, similarly to nuclear epigenetics, mtDNA methylation could affect the expression of mitochondrial genes and mtDNA copy number as well [26,27,28,29,30]

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The sequencing results showed that blueberry significantly increased the abundance of bacterial taxa negatively correlated with circulating TMA/TMAO, suggesting that it may affect TMAO synthesis by affecting the composition of gut microbiota