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In contrast, overexpression of SRXN1 showed a protective effect

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Preclinical evidence shows that polyphenols exert greater selectivity in tumor cells to target oxidative phosphorylation and regulation of the mitochondrial membrane potential (MMP), glycolysis, pro-oxidant pathways, and antioxidant (adaptive) stress responses and their anticancer efficacy relates to the protonophoric and pro-oxidant properties rather than the specific effects on downstream molecular targets affected by MMP dissipation and mitochondrial uncoupling [43]