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Microbial biosynthesis of stabilized OSC analogues - Engineering microbial chassis such as Escherichia coli or Saccharomyces cerevisiae to overexpress cysteine desulfurases, -glutamyltranspeptidases, or myrosinase-like enzymes enables controlled biosynthesis of sulfoxides, isothiocyanates, and sulfonyl derivatives with greater stability than their native plant precursors (Jara et al., 2021)

demonstrated that chlorogenic acid (CGA) treatment elevated NRF2 protein levels in retinal tissues, suggesting that CGA offers protective effects against glaucoma and holds promise as a potential therapeutic agent for the disease [74]

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In line, Prx6 knockout mice exhibit markedly reduced levels of GPX4 and other selenoproteins, with this decrease being particularly pronounced in the brain [177] , highlighting the critical role of this redoxin in selenium metabolism and providing a missing link in selenoprotein biology that explains how cells coordinate thiol and selenium metabolism to counteract lipid peroxidation