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Even some older tricyclic antidepressants, which are often known for being highly sedating, can cause insomnia

Sci Rep (2018) 8(1):8652

The follow-up deadline was June 2024 to evaluate treatment effects and disease progression (new cirrhosis, ascites, esophageal and gastric varices and rupture bleeding, liver cancer, etc.)

In addition to human studies, cell and murine studies should be conducted using more relevant models of exposure such as airliquid interface (ALI) cultures of primary cells and non-aqueous apical delivery of antioxidants and pollutants