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We introduce four chemicals (PQ, rotenone, 6-OHDA, and MPTP/MPP+) that were applied to create the PD model for their capability to cause PD-like neuron impairments and symptoms (Figure 3)

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Development of dyskinesias requires two things: the person with PD needs to be taking levodopa there needs to be a certain level of neurodegeneration in the brain This means that if you start taking levodopa and it causes dyskinesias that are bothersome, you can lower or stop levodopa (with your doctors guidance) and the dyskinesias should resolve