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Tilting the redox balance towards oxidative stress in nucleated cells, i.e., by increasing the ROS levels, normally leads to cell death (apoptosis) or to an acceleration in ageing [111]

Value assessment: Collectible value: Because this pack has remained unused and is in its original packaging, it may have collectible value among smoking history enthusiasts and collectors

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There have been a few prospective studies exploring the association of smoking and PAD, but they have some caveats, such as an inclusion of only women (16) or men (17), a simple categorization of smoking status (current, former, or never [4,18,20]), short follow-up time of 5 years (5), or limited information about duration of smoking cessation (19)