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29 The negative affect that typifies the response to nicotine withdrawal probably results in part from a cascade of events involving increased levels of extrahypothalamic corticotropin-releasing factor (CRF) and increased binding of CRF to corticotropin-releasing factor 1 (CRF1) receptors in the brain, thereby activating the CRFCRF1 receptor system, which mediates responses to stress

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