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Controversy: Whether current data justify clinical use in fertility, given limited human trials and mechanistic gaps

Overall, it is necessary to exercise caution when prescribing PPIs to patients with CDAD risk factors, such as long-term hospitalization and a history of CDAD

These are massive doses compared to the amounts found in the average multivitamin tablets (which are set according to the recommended daily intakes for adult males in the UK at around 1.4mg for B6 and 1.5g for B12)

This pattern is not unique to NAD+, as other nutrients or supplements have experienced similar cycles of hype, backlash, and eventual clarification through further, more rigorous research