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Both semaglutide and tirzepatide can lead to some muscle loss if weight is lost quickly without adequate protein intake or resistance training

Chemokines like CCL2, CCL5, and CXCR4 also appeared to be less expressed, along with a possible reduction in gp91phox, a component involved in oxidative stress

373 In summary, the concept of revitalizing tissue-specific stem cells to restore tissue function and, ultimately, rejuvenating the whole organism represents a promising avenue worthy of further exploration

Therefore, it is desirable to develop good and relevant in vitro models to study gill health and the impact of chemical and biological factors on gill functions