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Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects

First: PI3K/Akt/mTOR, which drives protein synthesis, glucose uptake (via GLUT4 translocation), and anti-apoptotic signaling (particularly relevant in muscle and neuronal tissue)

This concept is supported by the reduced ability (by 90) of IGF-I / osteoblasts to induce osteoclastogenesis of spleen cells cultured from WT mice (65)