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593 Reactive astrocytes play predominantly protective role, and inhibition of reactivity exacerbates pathology in AD animal models

A medical committee decided on the use of the metabolic cytoprotector levocarnitine (Carnimet, REB-PHARMA, Republic of Belarus) in a combined therapeutic regimen because of the lack of optimal efficacy of the previous therapeutic approach and the patient provided written consent

The accumulation of predominantly mitochondrial SOX observed in CB-839treated cells accompanied the impairment of mitochondrial glutaminase activity in the mitochondria and the depletion of the intermediates needed for glutathione synthesis

This process includes analyzing their physical, chemical, and biological attributes to gain a deeper understanding of their potential (Fig