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Another preparatory step involves biochemical screening to evaluate cardiovascular health, liver and kidney function, and electrolyte stability

Vunta H, Belda BJ, Arner RJ et al (2008) Selenium attenuates pro-inflammatory gene expression in macrophages

doi: 10.1007/s11060-023-04369-5

in vitro screening study of recombinant DIOs found that 411 (22.5%) of the 1851 compounds from the ToxCast Phase 2 and e1k libraries inhibited DIO1, DIO2 and/or DIO3 by more than 20%, and that 228 (12.5%) inhibited a DIO by at least 50% [112]