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Moderate hyperbilirubinemia is associated with health benefits in overweight and obese individuals, diseases associated with low-grade chronic inflammation with increased oxidative stress, but also with altered endocrine signalling ( 54 , 55 )

Astrocytes, in a similar vein, are classified into A1 and A2 subtypes, which bear functional resemblances to the M1 and M2 microglial phenotypes, respectively [128]

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These factors may lead to synovial hyperplasia, pannus formation, bone erosion, and eventually irreversible deformities [1, 2]