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Elevated SOD levels, averaging 2195.4 U/mL, are a hallmark of CRC, reflecting the bodys response to oxidative stress, with levels rising progressively with disease stage and malignancy

In a cohort study of 80 male patients with alcoholic cirrhosis and 70 healthy male non-alcoholic controls, MDA levels, a known marker of lipid peroxidation, were significantly higher in those with alcoholic cirrhosis.Additionally, a negative correlation was found between MDA levels and the activities of antioxidant enzymes such as superoxide dismutase (SOD), GPx, and glutathione (GSH), indicating heightened oxidative stress and impaired antioxidant defense in ALD patients (79) ( Figure 1 )

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As in previous studies [35], we demonstrated that distal lung fibroblasts derived from COPD patients have intrinsic defects in collagen I contraction compared to fibroblasts derived from former smokers without COPD